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Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations
The core domain of p53 is extremely susceptible to mutations that lead to loss of function. We analysed the stability and DNA-binding activity of such mutants to understand the mechanism of second-site suppressor mutations. Double-mutant cycles show that N239Y and N268D act as ‘global stability’ sup...
Tallennettuna:
| Julkaisussa: | EMBO J |
|---|---|
| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group
2000
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305574/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10654936/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.3.370 |
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