Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

The core domain of p53 is extremely susceptible to mutations that lead to loss of function. We analysed the stability and DNA-binding activity of such mutants to understand the mechanism of second-site suppressor mutations. Double-mutant cycles show that N239Y and N268D act as ‘global stability’ sup...

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Dades bibliogràfiques

Publicat a:	EMBO J
Autors principals:	Nikolova, Penka V., Wong, Kam-Bo, DeDecker, Brian, Henckel, Julia, Fersht, Alan R.
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2000
Matèries:	Articles
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305574/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10654936/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.3.370
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