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Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide

We designed a series of nine-residue peptides that bound to a defined site on the tumor suppressor p53 and stabilized it against denaturation. To test whether the peptides could act as chaperones and rescue the tumor-suppressing function of oncogenic mutants of p53 in living cells, we treated human...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Issaeva, Natalia, Friedler, Assaf, Bozko, Przemyslaw, Wiman, Klas G., Fersht, Alan R., Selivanova, Galina
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC263793/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14595027/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1835733100
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