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Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide
We designed a series of nine-residue peptides that bound to a defined site on the tumor suppressor p53 and stabilized it against denaturation. To test whether the peptides could act as chaperones and rescue the tumor-suppressing function of oncogenic mutants of p53 in living cells, we treated human...
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| Główni autorzy: | , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2003
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC263793/ https://ncbi.nlm.nih.gov/pubmed/14595027 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1835733100 |
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