Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide
We designed a series of nine-residue peptides that bound to a defined site on the tumor suppressor p53 and stabilized it against denaturation. To test whether the peptides could act as chaperones and rescue the tumor-suppressing function of oncogenic mutants of p53 in living cells, we treated human...
Guardado en:
| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2003
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC263793/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14595027/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1835733100 |
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