Nalaganje...
Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations
The core domain of p53 is extremely susceptible to mutations that lead to loss of function. We analysed the stability and DNA-binding activity of such mutants to understand the mechanism of second-site suppressor mutations. Double-mutant cycles show that N239Y and N268D act as ‘global stability’ sup...
Shranjeno v:
| Main Authors: | , , , , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2000
|
| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC305574/ https://ncbi.nlm.nih.gov/pubmed/10654936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.3.370 |
| Oznake: |
Označite
Brez oznak, prvi označite!
|