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Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations
The core domain of p53 is extremely susceptible to mutations that lead to loss of function. We analysed the stability and DNA-binding activity of such mutants to understand the mechanism of second-site suppressor mutations. Double-mutant cycles show that N239Y and N268D act as ‘global stability’ sup...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC305574/ https://ncbi.nlm.nih.gov/pubmed/10654936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.3.370 |
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