The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy

Clozapine, by virtue of its absence of extrapyramidal side effects and greater efficacy, revolutionized the treatment of schizophrenia, although the mechanisms underlying this exceptional activity remain controversial. Combining an unbiased cheminformatics and physical screening approach, we evaluat...

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書誌詳細
主要な著者: Yadav, Prem N, Abbas, Atheir I, Farrell, Martilias S, Setola, Vincent, Sciaky, Noah, Huang, Xi-Ping, Kroeze, Wesley K, Crawford, LaTasha K, Piel, David A, Keiser, Michael J, Irwin, John J, Shoichet, Brian K, Deneris, Evan S, Gingrich, Jay, Beck, Sheryl G, Roth, Bryan L
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2011
主題:
Original Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055689/
https://ncbi.nlm.nih.gov/pubmed/21048700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2010.195
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