The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy

Clozapine, by virtue of its absence of extrapyramidal side effects and greater efficacy, revolutionized the treatment of schizophrenia, although the mechanisms underlying this exceptional activity remain controversial. Combining an unbiased cheminformatics and physical screening approach, we evaluat...

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Autors principals: Yadav, Prem N, Abbas, Atheir I, Farrell, Martilias S, Setola, Vincent, Sciaky, Noah, Huang, Xi-Ping, Kroeze, Wesley K, Crawford, LaTasha K, Piel, David A, Keiser, Michael J, Irwin, John J, Shoichet, Brian K, Deneris, Evan S, Gingrich, Jay, Beck, Sheryl G, Roth, Bryan L
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055689/
https://ncbi.nlm.nih.gov/pubmed/21048700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2010.195
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