Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma ranks among the most lethal of human malignancies. Here, we assess the cooperative interactions of two signature mutations in mice engineered to sustain pancreas-specific Cre-mediated activation of a mutant Kras allele (Kras(G12D)) and deletion of a conditional Ink4a...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Aguirre, Andrew J., Bardeesy, Nabeel, Sinha, Manisha, Lopez, Lyle, Tuveson, David A., Horner, James, Redston, Mark S., DePinho, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC305262/
https://ncbi.nlm.nih.gov/pubmed/14681207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1158703
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares