Impaired JNK signaling cooperates with Kras(G12D) expression to accelerate pancreatic ductal adenocarcinoma

The c-Jun N-terminal protein kinase (JNK) and its two direct activators, namely the mitogen-activated protein kinase (MAPK) kinase 4 (MKK4) and MKK7, constitute a signaling node frequently mutated in human pancreatic ductal adenocarcinoma (PDAC). Here we demonstrate the cooperative interaction of en...

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Hauptverfasser: Davies, Clare C., Harvey, Emma, McMahon, Raymond F.T., Finegan, Katherine G., Connor, Frances, Davis, Roger J., Tuveson, David A., Tournier, Cathy
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058314/
https://ncbi.nlm.nih.gov/pubmed/24713432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2941
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