Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma ranks among the most lethal of human malignancies. Here, we assess the cooperative interactions of two signature mutations in mice engineered to sustain pancreas-specific Cre-mediated activation of a mutant Kras allele (Kras(G12D)) and deletion of a conditional Ink4a...

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Main Authors: Aguirre, Andrew J., Bardeesy, Nabeel, Sinha, Manisha, Lopez, Lyle, Tuveson, David A., Horner, James, Redston, Mark S., DePinho, Ronald A.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2003
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC305262/
https://ncbi.nlm.nih.gov/pubmed/14681207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1158703
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