Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma ranks among the most lethal of human malignancies. Here, we assess the cooperative interactions of two signature mutations in mice engineered to sustain pancreas-specific Cre-mediated activation of a mutant Kras allele (Kras(G12D)) and deletion of a conditional Ink4a...

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Bibliographic Details
Published in:Genes Dev
Main Authors: Aguirre, Andrew J., Bardeesy, Nabeel, Sinha, Manisha, Lopez, Lyle, Tuveson, David A., Horner, James, Redston, Mark S., DePinho, Ronald A.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2003
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Research Papers
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305262/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14681207/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1158703
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