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Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation
The Alzheimer's disease (AD)-associated ubiquilin-1 regulates proteasomal degradation of proteins, including presenilin (PS). PS-dependent γ-secretase generates β-amyloid (Aβ) peptides, which excessively accumulate in AD brain. Here we have characterized the effects of naturally occurring ubiqu...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2011
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3050036/ https://ncbi.nlm.nih.gov/pubmed/21143716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2010.01149.x |
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