Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation

The Alzheimer's disease (AD)-associated ubiquilin-1 regulates proteasomal degradation of proteins, including presenilin (PS). PS-dependent γ-secretase generates β-amyloid (Aβ) peptides, which excessively accumulate in AD brain. Here we have characterized the effects of naturally occurring ubiqu...

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Main Authors: Viswanathan, Jayashree, Haapasalo, Annakaisa, Böttcher, Claudia, Miettinen, Riitta, Kurkinen, Kaisa M.A., Lu, Alice, Thomas, Anne, Maynard, Christa J., Romano, Donna, Hyman, Bradley T., Berezovska, Oksana, Bertram, Lars, Soininen, Hilkka, Dantuma, Nico P., Tanzi, Rudolph E., Hiltunen, Mikko
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050036/
https://ncbi.nlm.nih.gov/pubmed/21143716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2010.01149.x
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