A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations

The majority of mitochondrial DNA (mtDNA) mutations that cause human disease are mild to moderately deleterious, yet many random mtDNA mutations would be expected to be severe. To determine the fate of the more severe mtDNA mutations, we introduced mtDNAs containing two mutations that affect oxidati...

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Autori principali: Fan, Weiwei, Waymire, Katrina G., Narula, Navneet, Li, Peng, Rocher, Christophe, Coskun, Pinar E., Vannan, Mani A., Narula, Jagat, MacGregor, Grant R., Wallace, Douglas C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049809/
https://ncbi.nlm.nih.gov/pubmed/18276892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1147786
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