Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition

Maternal inheritance of mtDNA is the rule in most animals, but the reasons for this pattern remain unclear. To investigate the consequence of overriding uniparental inheritance, we generated mice containing an admixture (heteroplasmy) of NZB and 129S6 mtDNAs in the presence of a congenic C57BL/6J nu...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sharpley, Mark S., Marciniak, Christine, Eckel-Mahan, Kristin, McManus, Meagan, Crimi, Marco, Waymire, Katrina, Lin, Chun Shi, Masubuchi, Satoru, Friend, Nicole, Koike, Maya, Chalkia, Dimitra, MacGregor, Grant, Sassone-Corsi, Paolo, Wallace, Douglas C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175720/
https://ncbi.nlm.nih.gov/pubmed/23063123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.09.004
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