Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition

Maternal inheritance of mtDNA is the rule in most animals, but the reasons for this pattern remain unclear. To investigate the consequence of overriding uniparental inheritance, we generated mice containing an admixture (heteroplasmy) of NZB and 129S6 mtDNAs in the presence of a congenic C57BL/6J nu...

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Detalhes bibliográficos
Main Authors: Sharpley, Mark S., Marciniak, Christine, Eckel-Mahan, Kristin, McManus, Meagan, Crimi, Marco, Waymire, Katrina, Lin, Chun Shi, Masubuchi, Satoru, Friend, Nicole, Koike, Maya, Chalkia, Dimitra, MacGregor, Grant, Sassone-Corsi, Paolo, Wallace, Douglas C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175720/
https://ncbi.nlm.nih.gov/pubmed/23063123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.09.004
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