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Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition

Maternal inheritance of mtDNA is the rule in most animals, but the reasons for this pattern remain unclear. To investigate the consequence of overriding uniparental inheritance, we generated mice containing an admixture (heteroplasmy) of NZB and 129S6 mtDNAs in the presence of a congenic C57BL/6J nu...

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Κύριοι συγγραφείς:	Sharpley, Mark S., Marciniak, Christine, Eckel-Mahan, Kristin, McManus, Meagan, Crimi, Marco, Waymire, Katrina, Lin, Chun Shi, Masubuchi, Satoru, Friend, Nicole, Koike, Maya, Chalkia, Dimitra, MacGregor, Grant, Sassone-Corsi, Paolo, Wallace, Douglas C.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	2012
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4175720/ https://ncbi.nlm.nih.gov/pubmed/23063123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.09.004
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Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition

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