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A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations
The majority of mitochondrial DNA (mtDNA) mutations that cause human disease are mild to moderately deleterious, yet many random mtDNA mutations would be expected to be severe. To determine the fate of the more severe mtDNA mutations, we introduced mtDNAs containing two mutations that affect oxidati...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3049809/ https://ncbi.nlm.nih.gov/pubmed/18276892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1147786 |
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