A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations

The majority of mitochondrial DNA (mtDNA) mutations that cause human disease are mild to moderately deleterious, yet many random mtDNA mutations would be expected to be severe. To determine the fate of the more severe mtDNA mutations, we introduced mtDNAs containing two mutations that affect oxidati...

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Главные авторы: Fan, Weiwei, Waymire, Katrina G., Narula, Navneet, Li, Peng, Rocher, Christophe, Coskun, Pinar E., Vannan, Mani A., Narula, Jagat, MacGregor, Grant R., Wallace, Douglas C.
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049809/
https://ncbi.nlm.nih.gov/pubmed/18276892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1147786
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