A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations

The majority of mitochondrial DNA (mtDNA) mutations that cause human disease are mild to moderately deleterious, yet many random mtDNA mutations would be expected to be severe. To determine the fate of the more severe mtDNA mutations, we introduced mtDNAs containing two mutations that affect oxidati...

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Huvudupphovsmän: Fan, Weiwei, Waymire, Katrina G., Narula, Navneet, Li, Peng, Rocher, Christophe, Coskun, Pinar E., Vannan, Mani A., Narula, Jagat, MacGregor, Grant R., Wallace, Douglas C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049809/
https://ncbi.nlm.nih.gov/pubmed/18276892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1147786
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