Progressive Neurodegeneration or Endogenous Compensation in an Animal Model of Parkinson's Disease Produced by Decreasing Doses of Alpha-Synuclein

The pathological hallmarks of Parkinson's disease (PD) are degeneration of dopamine (DA) neurons of the substantia nigra (SN) and the presence of alpha-synuclein (α-syn)-rich Lewy bodies in DA cells that remain. To model these aspects of the disease, we previously showed that high titer (5.1×10...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Koprich, James B., Johnston, Tom H., Huot, Philippe, Reyes, M. Gabriela, Espinosa, Maria, Brotchie, Jonathan M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2011
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049796/
https://ncbi.nlm.nih.gov/pubmed/21408191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017698
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