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Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease

Alpha-synuclein is a predominant player in the pathogenesis of Parkinson's Disease. However, despite extensive study for two decades, its physiological and pathological mechanisms remain poorly understood. Alpha-synuclein forms a perplexing web of interactions with lipids, trafficking machinery...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Wang, Ting, Hay, Jesse C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641903/
https://ncbi.nlm.nih.gov/pubmed/26617485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2015.00433
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