The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease

Elevated iron in the SNpc may play a key role in Parkinson’s disease (PD) neurodegeneration since drug candidates with high iron affinity rescue PD animal models, and one candidate, deferirpone, has shown efficacy recently in a phase two clinical trial. However, strong iron chelators may perturb ess...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Finkelstein, David I., Billings, Jessica L., Adlard, Paul A., Ayton, Scott, Sedjahtera, Amelia, Masters, Colin L., Wilkins, Simon, Shackleford, David M., Charman, Susan A., Bal, Wojciech, Zawisza, Izabela A, Kurowska, Ewa, Gundlach, Andrew L., Ma, Sheri, Bush, Ashley I., Hare, Dominic J., Doble, Philip A., Crawford, Simon, Gautier, Elisabeth CL., Parsons, Jack, Huggins, Penny, Barnham, Kevin J., Cherny, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490188/
https://ncbi.nlm.nih.gov/pubmed/28659169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0456-2
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