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Photoproduct frequency is not the major determinant of UV base substitution hot spots or cold spots in human cells.

The role of UV radiation-induced photoproducts in initiating base substitution mutations in human cells was examined by measuring photoproduct frequency distributions and mutations in a supF tRNA gene on a shuttle vector plasmid transfected into DNA repair-deficient cells (xeroderma pigmentosum, com...

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Bibliographische Detailangaben
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Brash, D E, Seetharam, S, Kraemer, K H, Seidman, M M, Bredberg, A
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1987
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304960/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3473483/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.11.3782
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