Valproic acid attenuates blood–brain barrier disruption in a rat model of transient focal cerebral ischemia: the roles of HDAC and MMP-9 inhibition

Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, is known to protect against cerebral ischemia. The effects of VPA on blood–brain barrier (BBB) disruption were investigated in rats subjected to transient middle cerebral artery occlusion (MCAO). Postischemic VPA treatment remarkably atten...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Wang, Zhifei, Leng, Yan, Tsai, Li-Kai, Leeds, Peter, Chuang, De-Maw
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2011
Aiheet:
Brief Communication
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049473/
https://ncbi.nlm.nih.gov/pubmed/20978517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.195
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