Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia

Early blood-brain barrier (BBB) disruption, resulting from excessive neurovascular proteolysis by matrix metalloproteinases (MMPs), is closely associated with hemorrhagic transformation events in ischemic stroke. We have shown that normobaric hyperoxia (NBO) treatment reduces MMP-9 increase in the i...

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Hauptverfasser: Liu, Wenlan, Hendren, Jill, Qin, Xu-Jun, Shen, Jiangang, Liu, Ke Jian
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676213/
https://ncbi.nlm.nih.gov/pubmed/19187098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2008.05821.x
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