Valproic acid attenuates blood–brain barrier disruption in a rat model of transient focal cerebral ischemia: the roles of HDAC and MMP-9 inhibition

Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, is known to protect against cerebral ischemia. The effects of VPA on blood–brain barrier (BBB) disruption were investigated in rats subjected to transient middle cerebral artery occlusion (MCAO). Postischemic VPA treatment remarkably atten...

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Библиографические подробности
Главные авторы: Wang, Zhifei, Leng, Yan, Tsai, Li-Kai, Leeds, Peter, Chuang, De-Maw
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2011
Предметы:
Brief Communication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049473/
https://ncbi.nlm.nih.gov/pubmed/20978517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.195
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