Valproic acid attenuates blood–brain barrier disruption in a rat model of transient focal cerebral ischemia: the roles of HDAC and MMP-9 inhibition

Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, is known to protect against cerebral ischemia. The effects of VPA on blood–brain barrier (BBB) disruption were investigated in rats subjected to transient middle cerebral artery occlusion (MCAO). Postischemic VPA treatment remarkably atten...

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Detalhes bibliográficos
Main Authors: Wang, Zhifei, Leng, Yan, Tsai, Li-Kai, Leeds, Peter, Chuang, De-Maw
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049473/
https://ncbi.nlm.nih.gov/pubmed/20978517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.195
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