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Potent and Selective Photo-inactivation of Proteins With Peptoid-Ruthenium Conjugates
Advances in high-throughput screening now enable the rapid discovery of bioactive small molecules, but these primary hits almost always exhibit modest potency. We report a strategy for the transformation of these hits into much more potent inhibitors without compound optimization. Appending a deriva...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3049443/ https://ncbi.nlm.nih.gov/pubmed/20228793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.333 |
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