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Conserved core of amyloid fibrils of wild type and A30P mutant α-synuclein

The major component of neural inclusions that are the pathological hallmark of Parkinson's disease are amyloid fibrils of the protein α-synuclein (aS). Here we investigated if the disease-related mutation A30P not only modulates the kinetics of aS aggregation, but also alters the structure of a...

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Detalhes bibliográficos
Main Authors: Cho, Min-Kyu, Kim, Hai-Young, Fernandez, Claudio O, Becker, Stefan, Zweckstetter, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048423/
https://ncbi.nlm.nih.gov/pubmed/21280130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.570
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