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Structural and mechanistic basis behind the inhibitory interaction of PcTS on α-synuclein amyloid fibril formation

The identification of aggregation inhibitors and the investigation of their mechanism of action are fundamental in the quest to mitigate the pathological consequences of amyloid formation. Here, characterization of the structural and mechanistic basis for the antiamyloidogenic effect of phthalocyani...

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Detalhes bibliográficos
Main Authors: Lamberto, Gonzalo R., Binolfi, Andrés, Orcellet, María L., Bertoncini, Carlos W., Zweckstetter, Markus, Griesinger, Christian, Fernández, Claudio O.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795524/
https://ncbi.nlm.nih.gov/pubmed/19948969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902603106
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