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Copper-free click conjugation of methotrexate to a PAMAM dendrimer platform
The synthesis of a generation 5 (G5) poly(amidoamine) (PAMAM) dendrimer platform having cyclooctyne ligands that were subsequently be used for a copper-free Huisgen 1,3-dipolar cycloaddition (click reaction) with azido modified methotrexate is described. The G5 PAMAM dendrimer was first partially (7...
Bewaard in:
| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048335/ https://ncbi.nlm.nih.gov/pubmed/21383864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2010.12.025 |
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