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The facile synthesis of multifunctional PAMAM dendrimer conjugates through copper-free click chemistry
The facile conjugation of three azido modified functionalities, namely a therapeutic drug (methotrexate), a targeting moiety (folic acid), and an imaging agent (fluorescein) with a G5 PAMAM dendrimer scaffold with cyclooctyne molecules at the surface through copper-free click chemistry is reported....
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3331967/ https://ncbi.nlm.nih.gov/pubmed/22480432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.03.052 |
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