Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria

Excessive release of proinflammatory cytokines by innate immune cells is an important component of the pathogenic basis of malaria. Proinflammatory cytokines are a direct output of Toll-like receptor (TLR) activation during microbial infection. Thus, interference with TLR function is likely to rende...

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Библиографические подробности
Главные авторы: Franklin, Bernardo S., Ishizaka, Sally T., Lamphier, Marc, Gusovsky, Fabian, Hansen, Hans, Rose, Jeffrey, Zheng, Wanjun, Ataíde, Marco Antônio, de Oliveira, Rosane B., Golenbock, Douglas T., Gazzinelli, Ricardo T.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2011
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048158/
https://ncbi.nlm.nih.gov/pubmed/21303985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015406108
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