UNC93B1 and Nucleic Acid-sensing Toll-like Receptors Mediate Host Resistance to Infection with Leishmania major

The mammalian homolog B1 of Unc-93 Caenorhabditis elegans known as UNC93B1 is a chaperone protein that mediates translocation of the nucleic acid-sensing Toll-like receptors (TLRs) from the endoplasmic reticulum to the endolysosomes. The triple deficient (UNC93B1 mutant) mice have a functional singl...

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Detalhes bibliográficos
Main Authors: Schamber-Reis, Bruno Luiz Fonseca, Petritus, Patricia M., Caetano, Braulia C., Martinez, Espiridion R., Okuda, Kendi, Golenbock, Douglas, Scott, Phillip, Gazzinelli, Ricardo T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591622/
https://ncbi.nlm.nih.gov/pubmed/23325805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.407684
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