UNC93B1 Mediates Host Resistance to Infection with Toxoplasma gondii

UNC93B1 associates with Toll-Like Receptor (TLR) 3, TLR7 and TLR9, mediating their translocation from the endoplasmic reticulum to the endolysosome, hence allowing proper activation by nucleic acid ligands. We found that the triple deficient ‘3d’ mice, which lack functional UNC93B1, are hyper-suscep...

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Bibliografiske detaljer
Main Authors: Melo, Mariane B., Kasperkovitz, Pia, Cerny, Anna, Könen-Waisman, Stephanie, Kurt-Jones, Evelyn A., Lien, Egil, Beutler, Bruce, Howard, Jonathan C., Golenbock, Douglas T., Gazzinelli, Ricardo T.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928809/
https://ncbi.nlm.nih.gov/pubmed/20865117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001071
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