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UNC93B1 Mediates Host Resistance to Infection with Toxoplasma gondii
UNC93B1 associates with Toll-Like Receptor (TLR) 3, TLR7 and TLR9, mediating their translocation from the endoplasmic reticulum to the endolysosome, hence allowing proper activation by nucleic acid ligands. We found that the triple deficient ‘3d’ mice, which lack functional UNC93B1, are hyper-suscep...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928809/ https://ncbi.nlm.nih.gov/pubmed/20865117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001071 |
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