UNC93B1 Mediates Host Resistance to Infection with Toxoplasma gondii

UNC93B1 associates with Toll-Like Receptor (TLR) 3, TLR7 and TLR9, mediating their translocation from the endoplasmic reticulum to the endolysosome, hence allowing proper activation by nucleic acid ligands. We found that the triple deficient ‘3d’ mice, which lack functional UNC93B1, are hyper-suscep...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Melo, Mariane B., Kasperkovitz, Pia, Cerny, Anna, Könen-Waisman, Stephanie, Kurt-Jones, Evelyn A., Lien, Egil, Beutler, Bruce, Howard, Jonathan C., Golenbock, Douglas T., Gazzinelli, Ricardo T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928809/
https://ncbi.nlm.nih.gov/pubmed/20865117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001071
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi