Ketones and lactate “fuel” tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

Previously, we proposed a new model for understanding the “Warburg effect” in tumor metabolism. In this scheme, cancer-associated fibroblasts undergo aerobic glycolysis and the resulting energy-rich metabolites are then transferred to epithelial cancer cells, where they enter the TCA cycle, resultin...

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Autors principals: Bonuccelli, Gloria, Tsirigos, Aristotelis, Whitaker-Menezes, Diana, Pavlides, Stephanos, Pestell, Richard G, Chiavarina, Barbara, Frank, Philippe G, Flomenberg, Neal, Howell, Anthony, Martinez-Outschoorn, Ubaldo E, Sotgia, Federica, Lisanti, Michael P
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047616/
https://ncbi.nlm.nih.gov/pubmed/20818174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.17.12731
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