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On the Origin of Ion Selectivity in the Cys-Loop Receptor Family
Agonist binding to Cys-loop receptors promotes a large transmembrane ion flux of several million cations or anions per second. To investigate structural bases for the rapid and charge-selective flux, we used all atom molecular dynamics (MD) simulations, X-ray crystallography, and single channel reco...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3047408/ https://ncbi.nlm.nih.gov/pubmed/19728176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12031-009-9260-1 |
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