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An Ion Selectivity Filter in the Extracellular Domain of Cys-loop Receptors Reveals Determinants for Ion Conductance

Neurotransmitter binding to Cys-loop receptors promotes a prodigious transmembrane flux of several million ions/s, but to date, structural determinants of ion flux have been identified flanking the membrane-spanning region. Using x-ray crystallography, sequence analysis, and single-channel recording...

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Bibliografiske detaljer
Main Authors: Hansen, Scott B., Wang, Hai-Long, Taylor, Palmer, Sine, Steven M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662287/
https://ncbi.nlm.nih.gov/pubmed/18940802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C800194200
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