Inhibition of NADPH oxidase by glucosylceramide confers chemoresistance

The bioactive sphingolipid ceramide induces oxidative stress by disrupting mitochondrial function and stimulating NADPH oxidase (NOX) activity, both implicated in cell death mechanisms. Many anticancer chemotherapeutics (anthracyclines, Vinca alkaloids, paclitaxel and fenretinide), as well as physio...

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Bibliografiske detaljer
Main Authors: Barth, Brian M, Gustafson, Sally J, Young, Megan M, Fox, Todd E, Shanmugavelandy, Sriram S, Kaiser, James M, Cabot, Myles C, Kester, Mark, Kuhn, Thomas B
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2010
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047104/
https://ncbi.nlm.nih.gov/pubmed/20935456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.11.13438
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