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Inhibition of NADPH oxidase by glucosylceramide confers chemoresistance
The bioactive sphingolipid ceramide induces oxidative stress by disrupting mitochondrial function and stimulating NADPH oxidase (NOX) activity, both implicated in cell death mechanisms. Many anticancer chemotherapeutics (anthracyclines, Vinca alkaloids, paclitaxel and fenretinide), as well as physio...
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| Huvudupphovsmän: | , , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Landes Bioscience
2010
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3047104/ https://ncbi.nlm.nih.gov/pubmed/20935456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.11.13438 |
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