Inhibition of NADPH oxidase by glucosylceramide confers chemoresistance

The bioactive sphingolipid ceramide induces oxidative stress by disrupting mitochondrial function and stimulating NADPH oxidase (NOX) activity, both implicated in cell death mechanisms. Many anticancer chemotherapeutics (anthracyclines, Vinca alkaloids, paclitaxel and fenretinide), as well as physio...

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Autori principali: Barth, Brian M, Gustafson, Sally J, Young, Megan M, Fox, Todd E, Shanmugavelandy, Sriram S, Kaiser, James M, Cabot, Myles C, Kester, Mark, Kuhn, Thomas B
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2010
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047104/
https://ncbi.nlm.nih.gov/pubmed/20935456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.11.13438
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