Inhibition of NADPH oxidase by glucosylceramide confers chemoresistance

The bioactive sphingolipid ceramide induces oxidative stress by disrupting mitochondrial function and stimulating NADPH oxidase (NOX) activity, both implicated in cell death mechanisms. Many anticancer chemotherapeutics (anthracyclines, Vinca alkaloids, paclitaxel and fenretinide), as well as physio...

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Bibliografiska uppgifter
Huvudupphovsmän: Barth, Brian M, Gustafson, Sally J, Young, Megan M, Fox, Todd E, Shanmugavelandy, Sriram S, Kaiser, James M, Cabot, Myles C, Kester, Mark, Kuhn, Thomas B
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2010
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047104/
https://ncbi.nlm.nih.gov/pubmed/20935456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.11.13438
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