Inhibition of NADPH oxidase by glucosylceramide confers chemoresistance

The bioactive sphingolipid ceramide induces oxidative stress by disrupting mitochondrial function and stimulating NADPH oxidase (NOX) activity, both implicated in cell death mechanisms. Many anticancer chemotherapeutics (anthracyclines, Vinca alkaloids, paclitaxel and fenretinide), as well as physio...

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Detaylı Bibliyografya
Asıl Yazarlar: Barth, Brian M, Gustafson, Sally J, Young, Megan M, Fox, Todd E, Shanmugavelandy, Sriram S, Kaiser, James M, Cabot, Myles C, Kester, Mark, Kuhn, Thomas B
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Landes Bioscience 2010
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047104/
https://ncbi.nlm.nih.gov/pubmed/20935456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.11.13438
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