Targeting Glucosylceramide Synthase Synergizes with C(6)-Ceramide Nanoliposomes to Induce Apoptosis in NK Leukemia

Natural killer cell leukemia is characterized by clonal expansion of CD3(−) NK cells and comprises both chronic and aggressive forms. Currently, no effective treatment exists, thus providing a need for identification of novel therapeutics. Lipidomic studies revealed dysregulated sphingolipid metabol...

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Detalhes bibliográficos
Publicado no:Leuk Lymphoma
Main Authors: Watters, Rebecca J., Fox, Todd E., Tan, Su-Fern, Shanmugavelandy, Sriram, Choby, Jacob E., Broeg, Kathleen, Liao, Jason, Kester, Mark, Cabot, Myles C., Loughran, Thomas P., Liu, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296321/
https://ncbi.nlm.nih.gov/pubmed/23181473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2012.752485
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