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Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia

The natural killer (NK) type of aggressive large granular lymphocytic (LGL) leukemia is a fatal illness that pursues a rapid clinical course. There are no effective therapies for this illness, and pathogenetic mechanisms remain undefined. Here we report that the survivin was highly expressed in both...

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Main Authors: Liu, Xin, Ryland, Lindsay, Yang, Jun, Liao, Aijun, Aliaga, Cesar, Watts, Rebecca, Tan, Su-Fern, Kaiser, James, Shanmugavelandy, Sriram S., Rogers, Andrew, Loughran, Kathleen, Petersen, Bailey, Yuen, Jonathan, Meng, Fanxue, Baab, Kendall Thomas, Jarbadan, Nancy Ruth, Broeg, Kathleen, Zhang, Ranran, Liao, Jason, Sayers, Thomas Joseph, Kester, Mark, Loughran, Thomas P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993625/
https://ncbi.nlm.nih.gov/pubmed/20671121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-271080
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