Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway

Large granular lymphocyte (LGL) leukemia results from chronic expansion of cytotoxic T cells or natural killer (NK) cells. Apoptotic resistance resulting from constitutive activation of survival signaling pathways is a fundamental pathogenic mechanism. Recent network modeling analyses identified pla...

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Detalhes bibliográficos
Main Authors: Yang, Jun, Liu, Xin, Nyland, Susan B., Zhang, Ranran, Ryland, Lindsay K., Broeg, Kathleen, Baab, Kendall Thomas, Jarbadan, Nancy Ruth, Irby, Rosalyn, Loughran, Thomas P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803691/
https://ncbi.nlm.nih.gov/pubmed/19880494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-06-223719
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