Phosphodiesterase 4 Inhibition Reduces Innate Immunity and Improves Isoniazid Clearance of Mycobacterium tuberculosis in the Lungs of Infected Mice

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is one of the leading infectious disease causes of morbidity and mortality worldwide. Though current antibiotic regimens can cure the disease, treatment requires at least six months of drug therapy. One reason for the long duration of ther...

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Main Authors: Koo, Mi-Sun, Manca, Claudia, Yang, Guibin, O'Brien, Paul, Sung, Nackmoon, Tsenova, Liana, Subbian, Selvakumar, Fallows, Dorothy, Muller, George, Ehrt, Sabine, Kaplan, Gilla
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045423/
https://ncbi.nlm.nih.gov/pubmed/21364878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017091
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