Phosphodiesterase-4 Inhibition Alters Gene Expression and Improves Isoniazid – Mediated Clearance of Mycobacterium tuberculosis in Rabbit Lungs

Tuberculosis (TB) treatment is hampered by the long duration of antibiotic therapy required to achieve cure. This indolent response has been partly attributed to the ability of subpopulations of less metabolically active Mycobacterium tuberculosis (Mtb) to withstand killing by current anti-TB drugs....

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Detalhes bibliográficos
Main Authors: Subbian, Selvakumar, Tsenova, Liana, O'Brien, Paul, Yang, Guibin, Koo, Mi-Sun, Peixoto, Blas, Fallows, Dorothy, Dartois, Veronique, Muller, George, Kaplan, Gilla
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174258/
https://ncbi.nlm.nih.gov/pubmed/21949656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002262
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