Identification of Human IKK-2 Inhibitors of Natural Origin (Part I): Modeling of the IKK-2 Kinase Domain, Virtual Screening and Activity Assays

BACKGROUND: Their large scaffold diversity and properties, such as structural complexity and drug similarity, form the basis of claims that natural products are ideal starting points for drug design and development. Consequently, there has been great interest in determining whether such molecules sh...

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Autores principales: Sala, Esther, Guasch, Laura, Iwaszkiewicz, Justyna, Mulero, Miquel, Salvadó, Maria-Josepa, Pinent, Montserrat, Zoete, Vincent, Grosdidier, Aurélien, Garcia-Vallvé, Santiago, Michielin, Olivier, Pujadas, Gerard
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044726/
https://ncbi.nlm.nih.gov/pubmed/21390216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016903
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