Identification of Human IKK-2 Inhibitors of Natural Origin (Part I): Modeling of the IKK-2 Kinase Domain, Virtual Screening and Activity Assays

BACKGROUND: Their large scaffold diversity and properties, such as structural complexity and drug similarity, form the basis of claims that natural products are ideal starting points for drug design and development. Consequently, there has been great interest in determining whether such molecules sh...

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Detalhes bibliográficos
Main Authors: Sala, Esther, Guasch, Laura, Iwaszkiewicz, Justyna, Mulero, Miquel, Salvadó, Maria-Josepa, Pinent, Montserrat, Zoete, Vincent, Grosdidier, Aurélien, Garcia-Vallvé, Santiago, Michielin, Olivier, Pujadas, Gerard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044726/
https://ncbi.nlm.nih.gov/pubmed/21390216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016903
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