ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis

Lymphocytes mediate cytotoxicity by polarized release of the contents of cytotoxic granules toward their target cells. Here, we have studied the role of the calcium release-activated calcium channel ORAI1 in human lymphocyte cytotoxicity. Natural killer (NK) cells obtained from an ORAI1-deficient pa...

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Detalles Bibliográficos
Autores principales: Maul-Pavicic, Andrea, Chiang, Samuel C. C., Rensing-Ehl, Anne, Jessen, Birthe, Fauriat, Cyril, Wood, Stephanie M., Sjöqvist, Sebastian, Hufnagel, Markus, Schulze, Ilka, Bass, Thilo, Schamel, Wolfgang W., Fuchs, Sebastian, Pircher, Hanspeter, McCarl, Christie-Ann, Mikoshiba, Katsuhiko, Schwarz, Klaus, Feske, Stefan, Bryceson, Yenan T., Ehl, Stephan
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2011
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044412/
https://ncbi.nlm.nih.gov/pubmed/21300876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013285108
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