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R93W mutation in Orai1 causes impaired calcium influx in platelets

The intracellular Ca(2+) concentration of many nonexcitable cells is regulated by calcium store release and store-operated calcium entry (SOCE). In platelets, STIM1 was recently identified as the main calcium sensor expressed in the endoplasmic reticulum. To evaluate the role of the SOC channel moie...

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Detalhes bibliográficos
Main Authors: Bergmeier, Wolfgang, Oh-hora, Masatsugu, McCarl, Christie-Ann, Roden, R. Claire, Bray, Paul F., Feske, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628374/
https://ncbi.nlm.nih.gov/pubmed/18952890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-174516
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