Store-operated Ca(2+) entry through ORAI1 is critical for T cell mediated autoimmunity and allograft rejection

ORAI1 is the pore forming subunit of the Ca(2+) release activated Ca(2+) (CRAC) channel, which is responsible for store-operated Ca(2+) entry (SOCE) in lymphocytes. A role for ORAI1 in T cell function in vivo has been inferred from in vitro studies of T cells from human immunodeficient patients with...

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Hlavní autoři: McCarl, Christie-Ann, Khalil, Sara, Ma, Jian, Oh-hora, Masatsugu, Yamashita, Megumi, Roether, Jens, Kawasaki, Takumi, Jairaman, Amit, Sasaki, Yoshiteru, Prakriya, Murali, Feske, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974040/
https://ncbi.nlm.nih.gov/pubmed/20956344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001796
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