ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

Store-operated Ca(2+) entry (SOCE) through Ca(2+) release-activated Ca(2+) (CRAC) channels is critical for lymphocyte function and immune responses. CRAC channels are hexamers of ORAI proteins that form the channel pore, but the contributions of individual ORAI homologues to CRAC channel function ar...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Vaeth, Martin, Yang, Jun, Yamashita, Megumi, Zee, Isabelle, Eckstein, Miriam, Knosp, Camille, Kaufmann, Ulrike, Karoly Jani, Peter, Lacruz, Rodrigo S., Flockerzi, Veit, Kacskovics, Imre, Prakriya, Murali, Feske, Stefan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355949/
https://ncbi.nlm.nih.gov/pubmed/28294127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14714
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