ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

Store-operated Ca(2+) entry (SOCE) through Ca(2+) release-activated Ca(2+) (CRAC) channels is critical for lymphocyte function and immune responses. CRAC channels are hexamers of ORAI proteins that form the channel pore, but the contributions of individual ORAI homologues to CRAC channel function ar...

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Publicat a:Nat Commun
Autors principals: Vaeth, Martin, Yang, Jun, Yamashita, Megumi, Zee, Isabelle, Eckstein, Miriam, Knosp, Camille, Kaufmann, Ulrike, Karoly Jani, Peter, Lacruz, Rodrigo S., Flockerzi, Veit, Kacskovics, Imre, Prakriya, Murali, Feske, Stefan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355949/
https://ncbi.nlm.nih.gov/pubmed/28294127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14714
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