ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis

Lymphocytes mediate cytotoxicity by polarized release of the contents of cytotoxic granules toward their target cells. Here, we have studied the role of the calcium release-activated calcium channel ORAI1 in human lymphocyte cytotoxicity. Natural killer (NK) cells obtained from an ORAI1-deficient pa...

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Detalhes bibliográficos
Main Authors: Maul-Pavicic, Andrea, Chiang, Samuel C. C., Rensing-Ehl, Anne, Jessen, Birthe, Fauriat, Cyril, Wood, Stephanie M., Sjöqvist, Sebastian, Hufnagel, Markus, Schulze, Ilka, Bass, Thilo, Schamel, Wolfgang W., Fuchs, Sebastian, Pircher, Hanspeter, McCarl, Christie-Ann, Mikoshiba, Katsuhiko, Schwarz, Klaus, Feske, Stefan, Bryceson, Yenan T., Ehl, Stephan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044412/
https://ncbi.nlm.nih.gov/pubmed/21300876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013285108
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