NOX3 NADPH Oxidase Couples Transient Receptor Potential Vanilloid 1 to Signal Transducer and Activator of Transcription 1-Mediated Inflammation and Hearing Loss

Transient receptor potential vanilloid 1 (TRPV1) is implicated in cisplatin ototoxicity. Activation of this channel by cisplatin increases reactive oxygen species generation, which contribute to loss of outer hair cells in the cochlea. Knockdown of TRPV1 by short interfering RNA protected against ci...

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Bibliographische Detailangaben
Hauptverfasser: Mukherjea, Debashree, Jajoo, Sarvesh, Sheehan, Kelly, Kaur, Tejbeer, Sheth, Sandeep, Bunch, Jennifer, Perro, Christopher, Rybak, Leonard P., Ramkumar, Vickram
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2011
Schlagworte:
Original Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043978/
https://ncbi.nlm.nih.gov/pubmed/20712533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2010.3497
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